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We read with interest the article by Ghika and Bogousslavsky¹ who found that 80% of their patients diagnosed as having progressive supranuclear palsy (PSP) had presymptomatic hypertension, suggesting that this might be a major feature in the diagnosis of PSP. However, we have not been able to confirm this finding in the setting of a multicenter case-control study of patients affected by PSP, designed to discern environmental and genetic factors possibly accounting for the pathogenesis of this disorder.²

After providing their informed consent, all consecutive patients with a possible diagnosis of PSP were screened in participating Italian centers from September 1995 to November 1997. Patients were diagnosed as having PSP according to the criteria of Golbe et al .³ All patients were seen by at least 1 neurologist, and all diagnoses have been confirmed independently by 2 neurologists from different centers, who have either reviewed the charts of the patients . . . [Full Text of this Article]

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Tau genotype: No effect on onset, symptom severity, or survival in progressive supranuclear palsy
Litvan et al.
Neurology 2001;57:138-140.
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