
Mass Effect in Progressive Multifocal Leukoencephalopathy
Arch Neurol. 1998;55:1148-1149.
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THE NEUROIMAGING features of progressive multifocal leukoencephalopathy (PML) are characterized by decreased attenuation on computed tomographic scans and an increased signal on T2-weighted magnetic resonance imaging scans, with lesions most often involving periventricular and subcortical white matter in parieto-occipital or frontal lobes and occasionally the posterior fossa, with rare enhancement and absence of mass effect.1 We describe a patient diagnosed as having PML by the findings of brain biopsy and cerebrospinal fluid polymerase chain reaction in whom the diagnosis was initially not considered because of the mass effect demonstrated on neuroimaging scans.
REPORT OF A CASE
A 44-year-old man presented with a 6-week history of progressive left-sided weakness and an 18-kg weight loss over several months. A computed tomographic scan and a magnetic resonance imaging scan of the head showed an area of abnormality in the right frontoparietal region, consistent with cerebral infarction. The patient's history was significant for intravenous drug use 4 . . . [Full Text of this Article] COMMENT
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