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William F. Forbes, PhD, DSc; Gerry B. Hill, MB, ChB, MSc, FRCPC
From the Elizabeth Bruyere Health Centre, Ottawa, Ontario

Arch Neurol. 1998;55:740-741.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE ANSWER to the question posed by this article's title is a qualified yes. McLachlan¹ reviews the evidence for the neurotoxicity of aluminum. Epidemiological studies have correlated the prevalence of Alzheimer disease (AD) and its mortality rate with levels of aluminum in drinking water in different geographical areas. While these ecological studies are inconclusive by design, they are supported by statistical data from both case-control and cohort studies. For example, McLachlan et al² show a strong association between aluminum concentrations in water and the prevalence of AD. Using autopsy-verified cases of AD, control subjects, and an aluminum concentration cutoff level of 100 µg/L, they determined that the odds ratio for developing AD was 2.6 (95% confidence interval [CI], 1.2-5.7). In addition, they found that the relative risk of developing AD increased with higher aluminum concentration cutoff levels: at . . . [Full Text of this Article]

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