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Stuart D. Cook, MD

Arch Neurol. 1998;55:421-423.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Progress in medical science is usually incremental, with each advance built on an ever-growing foundation shaped by prior investigations. These concepts are equally applicable to multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system with as yet neither a definitive cause nor a curative therapy. Considerable progress has been made in our knowledge of MS since the seminal descriptions of the disease in the late 19th and early 20th centuries. It is the purpose of this brief review to highlight some of the important historical contributions published prior to 1950 that have contributed to our present knowledge base.

DEFINITION OF MS

Clinical Features

Six years ago she noted her left leg resisted her will....Three months later the right leg was affected,...the upper extremities finally became...tremulous and weak....articulation was embarrassed...emotion difficult to describe...laughed and cried...involuntary movements....Swallowing was difficult...feebleness of vision.—Jean Cruveilhier, 1842^1-2

PATHOGENESIS

LABORATORY TESTS

CONCLUSIONS

From the Department of Neurosciences, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark

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