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Emerging Concepts

Andrew Kertesz, MD, FRCPC; David Munoz, MD, FRCPC

Arch Neurol. 1998;55:302-304.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Pick's disease has been relabeled recently as frontotemporal dementia (FTD) and the eponymic term restricted to the autopsy finding of typical inclusion bodies. Frontotemporal dementia is being used as a technical term in journals, while relatives of patients, the lay public, and many practitioners find Pick's disease (PiD), similar to Alzheimer's disease (AD), more acceptable. Furthermore, FTD commonly denotes the behavioral disorder, hindering the aphasic and extrapyramidal manifestations from being recognized as part of the syndrome. Recent advances in histochemistry suggest further fractionation, but the discovery of chromosome 17 localization of the familial forms of the disease suggests the cohesiveness of the clinical and biological entity.

PiD: A CLINICAL OR PATHOLOGICAL ENTITY?

Arnold Pick¹ described progressive aphasia and personality changes as the major clinical syndromes of frontotemporal atrophy more than 100 years ago. Subsequent focusing on round argyrophilic neuronal inclusions (Pick bodies) resulted in a confusing dichotomy over . . . [Full Text of this Article]

BEHAVIORAL, APHASIC, AND EXTRAPYRAMIDAL PRESENTATIONS OFTEN MERGE

CORTICOBASAL DEGENERATION IS PART OF THE PICK COMPLEX

MOTOR NEURON DISEASE (MND) IS AT TIMES ASSOCIATED WITH FTD AND PiD

PATHOLOGICAL SUBSTRATA OF PICK COMPLEX

HISTOPATHOLOGICAL FORMS LACK A DIRECT RELATIONSHIP TO CLINICAL SYNDROMES

GENETIC LINKAGE TO CHROMOSOME 17 OCCURS IN MOST FORMS OF FAMILIAL PICK COMPLEX

PICK COMPLEX IS A COMMON DEGENERATIVE DEMENTIA

From the Departments of Clinical Neurological Sciences (Dr Kertesz) and Pathology (Dr Munoz), University of Western Ontario, London.

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