This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (138)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Neurology  • Dementias  • Lewy Body Disease  • Movement Disorders  • Parkinson Disease/ Parkinsonian Disorders  • Alert me on articles by topic  Social Bookmarking   What's this?

Aggregation of Neurofilament and -Synuclein Proteins in Lewy Bodies

Implications for the Pathogenesis of Parkinson Disease and Lewy Body Dementia

John Q. Trojanowski, MD, PhD; Virginia M.-Y. Lee, PhD

Arch Neurol. 1998;55:151-152.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The presence of Lewy bodies (LBs) in dopaminergic neurons of the substantia nigra pars compacta, as well as neuron loss and gliosis, is a diagnostic hallmark of Parkinson disease (PD), but LBs also are seen in other cortical and subcortical neurons of the PD brain.^1-2 Additionally, LBs also occur in similar populations of neurons in the brains of patients with the classic clinical and pathological features of Alzheimer disease (AD).^1-2 Furthermore, the presence of numerous cortical intraneuronal LBs, but only rare AD neurofibrillary tangles and senile plaques in the brains of patients with an AD-like dementia, defines a neurodegenerative disorder known as dementia with LBs (DLB).^1-2 Ultrastructural examination of LBs has revealed masses of aggregated 7- to 25-nm-diameter filaments that appear similar to neurofilaments (NFs), but the precise molecular composition of LBs, including the abnormal filaments in these intracytoplasmic neuronal inclusions, . . . [Full Text of this Article]

From the Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in {alpha}-Synuclein Models of Parkinson's and Lewy Body Diseases
Spencer et al.
J. Neurosci. 2009;29:13578-13588.
ABSTRACT | FULL TEXT  

Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant {alpha}-Synuclein
Lu et al.
J. Neurosci. 2009;29:1962-1976.
ABSTRACT | FULL TEXT  

Review: Cellular repair strategies in Parkinson's disease
Winner et al.
Therapeutic Advances in Neurological Disorders 2009;2:51-60.
ABSTRACT  

{alpha}-Synuclein Alters Notch-1 Expression and Neurogenesis in Mouse Embryonic Stem Cells and in the Hippocampus of Transgenic Mice
Crews et al.
J. Neurosci. 2008;28:4250-4260.
ABSTRACT | FULL TEXT  

Transgenic Mice Overexpressing Tyrosine-to-Cysteine Mutant Human {alpha}-Synuclein: A PROGRESSIVE NEURODEGENERATIVE MODEL OF DIFFUSE LEWY BODY DISEASE
Zhou et al.
J. Biol. Chem. 2008;283:9863-9870.
ABSTRACT | FULL TEXT  

Ubiquitination of {alpha}-synuclein by Siah-1 promotes {alpha}-synuclein aggregation and apoptotic cell death
Lee et al.
Hum Mol Genet 2008;17:906-917.
ABSTRACT | FULL TEXT  

Identification of Novel Proteins Associated with Both {alpha}-Synuclein and DJ-1
Jin et al.
Mol. Cell. Proteomics 2007;6:845-859.
ABSTRACT | FULL TEXT  

{alpha}-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity
Kontopoulos et al.
Hum Mol Genet 2006;15:3012-3023.
ABSTRACT | FULL TEXT  

Regional Alpha-Synuclein Aggregation, Dopaminergic Dysregulation, and the Development of Drug-Related Visual Hallucinations in Parkinson's Disease
Papapetropoulos
J. Neuropsychiatry Clin. Neurosi. 2006;18:149-157.
ABSTRACT | FULL TEXT  

Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for {alpha}-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT
Stiasny-Kolster et al.
Brain 2005;128:126-137.
ABSTRACT | FULL TEXT  

Phenotypic analysis of neurofilament light gene mutations linked to Charcot-Marie-Tooth disease in cell culture models
Perez-Olle et al.
Hum Mol Genet 2004;13:2207-2220.
ABSTRACT | FULL TEXT  

Dementia with Lewy Bodies: Molecular Pathogenesis and Implications for Classification
Cummings
J Geriatr Psychiatry Neurol 2004;17:112-119.
ABSTRACT  

Hsp70 Reduces {alpha}-Synuclein Aggregation and Toxicity
Klucken et al.
J. Biol. Chem. 2004;279:25497-25502.
ABSTRACT | FULL TEXT  

Neurodegeneration in Normal Brain Aging and Disease
Thal et al.
Sci Aging Knowl Environ 2004;2004:pe26-pe26.
ABSTRACT | FULL TEXT  

Does {alpha}-synuclein modulate dopaminergic synaptic content and tone at the synapse?
SIDHU et al.
FASEB J. 2004;18:637-647.
ABSTRACT | FULL TEXT  

Lewy body cortical involvement may not always predict dementia in Parkinson's disease
Colosimo et al.
J. Neurol. Neurosurg. Psychiatry 2003;74:852-856.
ABSTRACT | FULL TEXT  

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration
Corti et al.
Hum Mol Genet 2003;12:1427-1437.
ABSTRACT | FULL TEXT  

gamma -Synuclein Promotes Cancer Cell Survival and Inhibits Stress- and Chemotherapy Drug-induced Apoptosis by Modulating MAPK Pathways
Pan et al.
J. Biol. Chem. 2002;277:35050-35060.
ABSTRACT | FULL TEXT  

Research Evaluation and Prospective Diagnosis of Dementia With Lewy Bodies
Lopez et al.
Arch Neurol 2002;59:43-46.
ABSTRACT | FULL TEXT  

Attenuated Neurodegenerative Disease Phenotype in Tau Transgenic Mouse Lacking Neurofilaments
Ishihara et al.
J. Neurosci. 2001;21:6026-6035.
ABSTRACT | FULL TEXT  

Direct binding and functional coupling of {alpha}-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis
LEE et al.
FASEB J. 2001;15:916-926.
ABSTRACT | FULL TEXT  

Molecular Etiology of Parkinson Disease: Recent Progress
Shastry
Neuroscientist 2000;6:234-240.
ABSTRACT  

{alpha}-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress
Hsu et al.
Am. J. Pathol. 2000;157:401-410.
ABSTRACT | FULL TEXT  

Evidence for Seeding of beta -Amyloid by Intracerebral Infusion of Alzheimer Brain Extracts in beta -Amyloid Precursor Protein-Transgenic Mice
Kane et al.
J. Neurosci. 2000;20:3606-3611.
ABSTRACT | FULL TEXT  

Severity of cognitive impairment and the clinical diagnosis of AD with Lewy bodies
Lopez et al.
Neurology 2000;54:1780-1787.
ABSTRACT | FULL TEXT  

Dopaminergic Loss and Inclusion Body Formation in -Synuclein Mice: Implications for Neurodegenerative Disorders
Masliah et al.
Science 2000;287:1265-1269.
ABSTRACT | FULL TEXT  

Degradation of alpha -Synuclein by Proteasome
Bennett et al.
J. Biol. Chem. 1999;274:33855-33858.
ABSTRACT | FULL TEXT  

Clinical and quantitative pathologic correlates of dementia with Lewy bodies
Gomez-Tortosa et al.
Neurology 1999;53:1284-1284.
ABSTRACT | FULL TEXT  

The G209A Mutation in the {alpha}-Synuclein Gene Is Not Detected in Familial Cases of Parkinson Disease in Non-Greek and/or Italian Populations
Wang et al.
Arch Neurol 1998;55:1521-1523.
ABSTRACT | FULL TEXT  

The Herbicide Paraquat Causes Up-regulation and Aggregation of alpha -Synuclein in Mice. PARAQUAT AND alpha -SYNUCLEIN
Manning-Bog et al.
J. Biol. Chem. 2002;277:1641-1644.
ABSTRACT | FULL TEXT  

alpha -Synuclein Membrane Interactions and Lipid Specificity
Jo et al.
J. Biol. Chem. 2000;275:34328-34334.
ABSTRACT | FULL TEXT