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The conclusions of Lipton et al¹ that the combination of aspirin, acetaminophen, and caffeine was highly effective for the treatment of migraine headache symptoms requires further comment. They acknowledge in their "Patients and Methods" section that the most severely disabled segment of migraineurs was excluded. However, they do not tell us what percentage of the potential population was excluded for this reason. In a previous article² by the first 2 authors of the current study, severe disability was identified in 50% of migraineurs who had been diagnosed by a physician and 25% of migraineurs who had not been previously diagnosed.

The lack of relapse data is surprising in any study of an acute headache treatment and is a major limitation of this study.

I would suggest the conclusion should be limited to say that, for migraineurs who are not usually severely disabled, the combination of aspirin, acetaminophen, and caffeine produces . . . [Full Text of this Article]

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Efficacy and Safety of Acetaminophen in the Treatment of Migraine: Results of a Randomized, Double-blind, Placebo-Controlled, Population-Based Study
Lipton et al.
Arch Intern Med 2000;160:3486-3492.
ABSTRACT | FULL TEXT