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A New Risk Factor for Alzheimer Disease?

Arch Neurol. 1998;55:1407-1408.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

JUDGING BY the number of citations in the medical literature, the lay press, and the Internet, homocysteine is the favorite amino acid of the late 1990s. This is primarily because of the recognition during the past several years that hyperhomocysteinemia is an important risk factor for vascular disease, independent of long-recognized factors such as hyperlipidemia, hypertension, and smoking. A wealth of epidemiological data has accumulated in support of the hypothesis initially advanced by Kilmer McCully in 1969,¹ which was based on autopsy findings from 2 children with elevated plasma homocysteine levels. By now, more than 20 case-control and cross-sectional studies, involving more than 15000 patients, have validated this correlation.² A recent meta-analysis by Boushey et al³ estimated that 10% of the risk of coronary artery disease in the general population is due to homocysteine.³ Of particular importance to neurologists is the increased prevalence of cerebrovascular disease in patients whose homocysteine . . . [Full Text of this Article]

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