 |
|
Gene Therapy for Neurological Disorders and Brain Tumors
edited by E. Antonio Chiocca, Xandra O. Breakefield, 550 pp, $135, Totowa, NJ, Humana Press, 1997.
Arch Neurol. 1998;55:1375.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
In contemporary medicine, the latency between basic scientific advancements and clinical application is disconcertingly brief. The rapid emergence of gene therapy for neurologic disorders is a remarkable example of such progress. This book edited by Chiocca and Breakefield provides a sophisticated authoritative overview of this exciting new area. The 550-page hardbound book is divided into 3 parts covering vectors and promoters, applications of gene therapy to neuro-oncology, and gene therapy in nonneoplastic disorders.
Beginning with a lucid overview by J. Glorioso of vectors used for gene transfer to the nervous system, other active investigators provide 9 chapters discussing the major vectors currently under investigation in gene therapy, promoters allowing regulation of expression of the newly introduced genes, and the host immune response to viral vectors. Retrovirus, adenovirus, herpes simplex virus, adeno-associated virus, Epstein-Barr virus, and lentivirus vectors are discussed in sufficient detail such that a newcomer can understand the elements . . . [Full Text of this Article]
|
