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Do Nonconvulsive Seizures Damage the Brain?—No
Michael J. Aminoff, MD, FRCP
From the Department of Neurology, School of Medicine, University of California, San Francisco.
Arch Neurol. 1998;55:119-120.
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WHEN attempting to determine whether nonconvulsive seizures cause brain damage, it is appropriate to examine initially whether nonconvulsive status epilepticus produces such damage. If it does, the aggressive treatment of this form of status epilepticus may be justified despite the potential morbidity of certain therapeutic approaches. If it does not, it may reasonably be concluded that isolated nonconvulsive seizures also fail to produce brain damage. To my knowledge, there is no information to indicate whether isolated nonconvulsive seizures recurring over many years are harmful, although it is pertinent that a benign course and an excellent prognosis for remission without evidence of cerebral damage are associated with certain hereditary, childhood-onset, nonconvulsive seizure disorders.
Nonconvulsive status epilepticus may be difficult to identify. Some patients with Lennox-Gastaut syndrome, for example, show near-continuous atypical spike-wave activity in the electroencephalogram and a variable state of mental dullness, but it is . . . [Full Text of this Article]
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