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A Summary Risk Score for the Prediction of Alzheimer Disease in Elderly Persons
Christiane Reitz, MD, PhD;
Ming-Xin Tang, PhD;
Nicole Schupf, PhD;
Jennifer J. Manly, PhD;
Richard Mayeux, MD, MSc;
José A. Luchsinger, MD, MPH
Arch Neurol. 2010;67(7):835-841. doi:10.1001/archneurol.2010.136
Objective To develop a simple summary risk score for the prediction of Alzheimer disease in elderly persons based on their vascular risk profiles.
Design A longitudinal, community-based study.
Setting New York, New York.
Patients One thousand fifty-one Medicare recipients aged 65 years or older and residing in New York who were free of dementia or cognitive impairment at baseline.
Main Outcome Measures We separately explored the associations of several vascular risk factors with late-onset Alzheimer disease (LOAD) using Cox proportional hazards models to identify factors that would contribute to the risk score. Then we estimated the score values of each factor based on their β coefficients and created the LOAD vascular risk score by summing these individual scores.
Results Risk factors contributing to the risk score were age, sex, education, ethnicity, APOE  4 genotype, history of diabetes, hypertension or smoking, high-density lipoprotein levels, and waist to hip ratio. The resulting risk score predicted dementia well. According to the vascular risk score quintiles, the risk to develop probable LOAD was 1.0 for persons with a score of 0 to 14 and increased 3.7-fold for persons with a score of 15 to 18, 3.6-fold for persons with a score of 19 to 22, 12.6-fold for persons with a score of 23 to 28, and 20.5-fold for persons with a score higher than 28.
Conclusions While additional studies in other populations are needed to validate and further develop the score, our study suggests that this vascular risk score could be a valuable tool to identify elderly individuals who might be at risk of LOAD. This risk score could be used to identify persons at risk of LOAD, but can also be used to adjust for confounders in epidemiologic studies.
Authors Affiliations: The Gertrude H. Sergievsky Center (Drs Reitz, Tang, Schupf, Manly, Mayeux, and Luchsinger); The Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Drs Reitz, Schupf, Manly, Mayeux, and Luchsinger); the Departments of Neurology (Drs Reitz, Manly, and Mayeux), Psychiatry (Drs Schupf and Mayeux), and Medicine (Dr Luchsinger); and Departments of Biostatistics (Dr Tang) and Epidemiology (Drs Schupf and Mayeux), Mailman School of Public Health, Columbia University College of Physicians and Surgeons, New York, New York.
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