• Online Features  This Article  • Full text  • PDF  • eTables  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (11)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Aging/ Geriatrics  • Neurology  • Alzheimer Disease  • Cognitive Disorders  • Dementias  • Nutritional and Metabolic Disorders  • Lipids and Lipid Disorders  • Alert me on articles by topic  Social Bookmarking   What's this?

Christiane Reitz, MD, PhD; Ming-Xin Tang, PhD; Nicole Schupf, PhD; Jennifer J. Manly, PhD; Richard Mayeux, MD, MSc; José A. Luchsinger, MD, MPH

Arch Neurol. 2010;67(12):1491-1497. doi:10.1001/archneurol.2010.297

Objective  To reexamine the association of lipid levels with Alzheimer disease (AD) using Cox proportional hazards models.

Design  Prospective cohort study.

Setting  Northern Manhattan, New York.

Participants  One thousand one hundred thirty elderly individuals free of cognitive impairment at baseline.

Main Outcome Measure  High-density lipoprotein cholesterol (HDL-C) levels.

Results  Higher levels of HDL-C (>55 mg/dL) were associated with a decreased risk of both probable and possible AD and probable AD compared with lower HDL-C levels (hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P = .03 and hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P = .03). In addition, higher levels of total and non–HDL-C were associated with a decreased risk of AD in analyses adjusting for age, sex, education, ethnic group, and APOE e4 genotype.

Conclusion  High HDL-C levels in elderly individuals may be associated with a decreased risk of AD.

Author Affiliations: Gertrude H. Sergievsky Center (Drs Reitz, Tang, Schupf, Manly, Mayeux, and Luchsinger), Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Drs Reitz, Schupf, Manly, Mayeux, and Luchsinger), Departments of Neurology (Drs Reitz, Manly, and Mayeux), Medicine (Dr Luchsinger), and Psychiatry (Drs Schupf and Mayeux), and Departments of Biostatistics (Dr Tang) and Epidemiology (Drs Schupf and Mayeux), Mailman School of Public Health, Columbia University College of Physicians and Surgeons, New York, New York.

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Mild Hypercholesterolemia, Normal Plasma Triglycerides, and Normal Glucose Levels Across Dementia Staging in Alzheimer's Disease: A Clinical Setting-Based Retrospective Study
Ramdane and Daoudi-Gueddah
AM J ALZHEIMERS DIS OTHER DEMEN 2011;26:399-405.
ABSTRACT  

Accuracy of Summary Risk Score for Prediction of Alzheimer Disease: Better Than Demographics Alone?--Reply
Reitz et al.
Arch Neurol 2011;68:268-270.
FULL TEXT