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James M. Noble, MD, MS; Jennifer J. Manly, PhD; Nicole Schupf, PhD; Ming Xing Tang, PhD; Richard Mayeux, MD, MS; José A. Luchsinger, MD, MPH

Arch Neurol. 2010;67(1):87-92.

Background  High-sensitivity C-reactive protein (hsCRP) is a biomarker of cardiovascular risk that is suggested to be a biomarker for cognitive impairment.

Objective  To explore the association between hsCRP and cognitive impairment.

Design  Cross-sectional analysis of a population-based community aging study.

Setting  Northern Manhattan, New York, New York.

Other Participants  One thousand three hundred thirty-one participants from a longitudinal study of aging without dementia and with available hsCRP and neuropsychological testing data at baseline.

Main Outcome Measures  Four cognitive scores (memory, visuospatial, executive, and language impairment) derived from a neuropsychological battery. Cognitive impairment was defined by scores below 1.5 SDs of demographically corrected means.

Results  Participants in the highest hsCRP tertile had higher adjusted odds of impaired memory (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.0-2.1; P = .03) than participants in the lowest tertile. Subjects in the highest hsCRP tertile also had greater odds of visuospatial impairment (OR, 1.6; 95% CI, 1.0-2.3; P = .03). Higher hsCRP was not associated with executive or language impairment. Persons with at least 1 APOE 4 allele and hsCRP in the highest tertile had the greatest odds of impaired memory (OR, 2.7; 95% CI, 1.6-4.4).

Conclusions  High hsCRP may be a marker of memory and visuospatial impairment in the elderly. The role of APOE 4 requires further exploration.

Author Affiliations: Gertrude H. Sergievsky Center, Columbia University (Drs Noble, Manly, Schupf, Tang, Mayeux, and Luchsinger); Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Columbia University (Drs Noble, Manly, Schupf, Mayeux, and Luchsinger); Departments of Neurology (Drs Noble and Mayeux) and Psychiatry (Dr Mayeux), and Division of General Medicine, Department of Medicine (Dr Luchsinger), Columbia University College of Physicians and Surgeons; and Departments of Epidemiology (Drs Schupf, Mayeux, and Luchsinger) and Biostatistics (Dr Tang), Joseph P. Mailman School of Public Health, Columbia University, New York, New York.

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