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Focal Primary Motor Cortex Hypometabolism Seen on Fluorodeoxyglucose F18 Positron Emission Tomography

Daniel O. Claassen, MD; Keith A. Josephs, MD; Patrick J. Peller, MD

Arch Neurol. 2010;67(1):122-125.

Background  Primary lateral sclerosis (PLS) is a progressive upper motor neuron neurodegenerative condition. The diagnosis is made using clinical history, objective neurological assessment, and exclusion of other neurodegenerative disorders.

Objective  To evaluate the role of fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection in the diagnosis of PLS.

Design  Case series.

Setting  Outpatient neurology clinic.

Patients  Three cases of probable PLS.

Intervention  Fluorodeoxyglucose F18 positron emission tomography in 3 patients with PLS.

Results  Three patients (2 male and 1 female; mean age, 65 years) were identified with a clinical diagnosis of PLS. Fluorodeoxyglucose F18 positron emission tomography demonstrated varying degrees of primary motor cortex hypometabolism.

Conclusion  Fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection provide a useful diagnostic method to support a clinical diagnosis of PLS.

Author Affiliations: Departments of Neurology (Drs Claassen and Josephs) and Radiology (Dr Peller), Mayo Clinic and Mayo College of Medicine, Rochester, Minnesota.

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