 |
|
Difference in Disease Burden and Activity in Pediatric Patients on Brain Magnetic Resonance Imaging at Time of Multiple Sclerosis Onset vs Adults
Emmanuelle Waubant, MD, PhD;
Dorothee Chabas, MD, PhD;
Darin T. Okuda, MD, MSc;
Orit Glenn, MD;
Ellen Mowry, MD;
Roland G. Henry, PhD;
Jonathan B. Strober, MD;
Bruno Soares, MD;
Max Wintermark, MD;
Daniel Pelletier, MD
Arch Neurol. 2009;66(8):967-971.
Objective To compare initial brain magnetic resonance imaging (MRI) characteristics of children and adults at multiple sclerosis (MS) onset.
Design Retrospective analysis of features of first brain MRI available at MS onset in patients with pediatric-onset and adult-onset MS.
Setting A pediatric and an adult MS center.
Patients Patients with pediatric-onset <18 years) and adult-onset ( 18 years) MS.
Main Outcome Measures We evaluated initial and second (when available) brain MRI scans obtained at the time of first MS symptoms for lesions that were T2-bright, ovoid and well defined, large (1cm), or enhancing.
Results We identified 41 patients with pediatric-onset MS and 35 patients with adult-onset MS. Children had a higher number of total T2- (median, 21 vs 6; P < .001) and large T2-bright areas (median, 4 vs 0; P < .001) than adults. Children more frequently had T2-bright foci in the posterior fossa (68.3% vs 31.4%; P = .001) and enhancing lesions (68.4% vs 21.2%; P < .001) than adults. On the second brain MRI, children had more new T2-bright (median, 2.5 vs 0; P < .001) and gadolinium-enhancing foci (P < .001) than adults. Except for corpus callosum involvement, race/ethnicity was not strongly associated with disease burden or lesion location on the first scan, although other associations cannot be excluded because of the width of the confidence intervals.
Conclusion While it is unknown whether the higher disease burden, posterior fossa involvement, and rate of new lesions in pediatric-onset MS are explained by age alone, these characteristics have been associated with worse disability progression in adults.
Author Affiliations: UCSF Regional Pediatric Multiple Sclerosis Center (Drs Waubant, Chabas, and Strober), UCSF Adult Multiple Sclerosis Center (Drs Okuda, Mowry, and Pelletier), and Department of Radiology, University of California, San Francisco (Drs Glenn, Henry, Soares, and Wintermark).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
RELATED ARTICLE
This Month in Archives of Neurology
Arch Neurol. 2009;66(8):929-930.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Reduced head and brain size for age and disproportionately smaller thalami in child-onset MS
Kerbrat et al.
Neurology 2012;78:194-201.
ABSTRACT
| FULL TEXT
Consensus statement: evaluation of new and existing therapeutics for pediatric multiple sclerosis
Chitnis et al.
Mult Scler 2012;18:116-127.
ABSTRACT
| FULL TEXT
Brain macro- and microscopic damage in patients with paediatric MS
Absinta et al.
J. Neurol. Neurosurg. Psychiatry 2010;81:1357-1362.
ABSTRACT
| FULL TEXT
Meeting Review: The management of multiple sclerosis in children: a European view
Ghezzi et al.
Mult Scler 2010;16:1258-1267.
ABSTRACT
Cognitive and psychosocial features in childhood and juvenile MS: Two-year follow-up
Amato et al.
Neurology 2010;75:1134-1140.
ABSTRACT
| FULL TEXT
Safety and efficacy of natalizumab in children with multiple sclerosis
Ghezzi et al.
Neurology 2010;75:912-917.
ABSTRACT
| FULL TEXT
Magnetic resonance imaging characteristics of children and adults with paediatric-onset multiple sclerosis
Yeh et al.
Brain 2009;132:3392-3400.
ABSTRACT
| FULL TEXT
|
