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Marc A. Dichter, MD, PhD

Arch Neurol. 2009;66(4):443-447.

Recent studies of the problem of ictogenesis, or the ways that seizures develop in an already hyperexcitable brain, are leading to paradigm-shifting concepts that may lead to exciting new therapies for seizures. Research on the equally important area of epileptogenesis, or the ways that a normal brain becomes epileptic, is also expanding, but comparable research into translation of laboratory findings into successful clinical interventions for those at high risk needs to be developed.

Author Affiliation: Department of Neurology, University of Pennsylvania, Philadelphia.

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