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Nikolaos Scarmeas, MD; Yaakov Stern, PhD; Richard Mayeux, MD; Jennifer J. Manly, PhD; Nicole Schupf, PhD; Jose A. Luchsinger, MD

Arch Neurol. 2009;66(2):216-225.

Background  Higher adherence to the Mediterranean diet (MeDi) may protect from Alzheimer disease (AD), but its association with mild cognitive impairment (MCI) has not been explored.

Objective  To investigate the association between the MeDi and MCI.

Design, Setting, and Patients  In a multiethnic community study in New York, we used Cox proportional hazards to investigate the association between adherence to the MeDi (0-9 scale; higher scores indicate higher adherence) and (1) the incidence of MCI and (2) the progression from MCI to AD. All of the models were adjusted for cohort, age, sex, ethnicity, education, APOE genotype, caloric intake, body mass index, and duration between baseline dietary assessment and baseline diagnosis.

Main Outcome Measures  Incidence of MCI and progression from MCI to AD.

Results  There were 1393 cognitively normal participants, 275 of whom developed MCI during a mean (SD) follow-up of 4.5 (2.7) years (range, 0.9-16.4 years). Compared with subjects in the lowest MeDi adherence tertile, subjects in the middle tertile had 17% less risk (hazard ratio [HR] = 0.83; 95% confidence interval [CI], 0.62-1.12; P = .24) of developing MCI and those in the highest tertile had 28% less risk (HR = 0.72; 95% CI, 0.52-1.00; P = .05) of developing MCI (trend HR = 0.85; 95% CI, 0.72-1.00; P for trend = .05). There were 482 subjects with MCI, 106 of whom developed AD during a mean (SD) follow-up of 4.3 (2.7) years (range, 1.0-13.8 years). Compared with subjects in the lowest MeDi adherence tertile, subjects in the middle tertile had 45% less risk (HR = 0.55; 95% CI, 0.34-0.90; P = .01) of developing AD and those in the highest tertile had 48% less risk (HR = 0.52; 95% CI, 0.30-0.91; P = .02) of developing AD (trend HR = 0.71; 95% CI, 0.53-0.95; P for trend = .02).

Conclusions  Higher adherence to the MeDi is associated with a trend for reduced risk of developing MCI and with reduced risk of MCI conversion to AD.

Author Affiliations: Departments of Neurology (Drs Scarmeas, Stern, Mayeux, and Manly) and Medicine (Dr Luchsinger), the Gertrude H. Sergievsky Center (Drs Scarmeas, Stern, Mayeux, Manly, and Schupf), and the Taub Institute for Research in Alzheimer's Disease and the Aging Brain (Drs Scarmeas, Stern, Mayeux, Manly, Schupf, and Luchsinger), Columbia University Medical Center, New York, New York.

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