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  Vol. 66 No. 10, October 2009 TABLE OF CONTENTS
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Implication of Sex and SORL1 Variants in Italian Patients With Alzheimer Disease

Elena Cellini, PhD; Andrea Tedde, PhD; Silvia Bagnoli, PhD; Silvia Pradella, MD; Silvia Piacentini, MD; Sandro Sorbi, MD; Benedetta Nacmias, PhD

Arch Neurol. 2009;66(10):1260-1266.

Objective  To investigate the association of genetic variants in sortilin-related receptor (SORL1), which has been proposed as an important genetic contributor to late-onset Alzheimer disease (LOAD).

Design  We analyzed 13 SORL1 single-nucleotide polymorphisms (SNPs) and the relative haplotypes in a case-control association study.

Participants  The sample included 708 Italian subjects: 251 unrelated, sporadic patients with LOAD, 99 sporadic patients with early-onset Alzheimer disease (AD), and 358 healthy controls.

Main Outcome Measures  We analyzed the 13 SNPs in the SORL1 gene that had been studied in previous reports using case-control methods and included sex, apolipoprotein E (APOE) genotype, and age at AD onset as covariates.

Results  The SNPs 4 (rs661057), 7 (rs12364988), and 10 (rs641120) were significantly associated with LOAD compared with controls. We found an association between these 3 variants and sex, suggesting that SORL1 may possibly affect LOAD through a female-specific mechanism. Of interest, the association of these SNPs with LOAD was confined to APOE {varepsilon}4 noncarriers. Several haplotypic associations at the 5' end of SORL1 were found, including the previously associated CGC haplotype at SNPs 8 through 10.

Conclusions  Our results confirm the association of SORL1 with AD and show a possible effect of female sex, suggesting that this gene may be a promising susceptibility factor for LOAD. Further studies to detect pathogenic variants and further elucidate the effect of SORL1 on the development of AD are necessary.


Author Affiliations: Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy.



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Arch Neurol. 2009;66(10):1190-1191.
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