 |
|
White Matter Changes in Corticobasal Degeneration Syndrome and Correlation With Limb Apraxia
Barbara Borroni, MD;
Valentina Garibotto, MD;
Chiara Agosti, MD;
Simona Maria Brambati, PhD;
Giuseppe Bellelli, MD;
Roberto Gasparotti, MD;
Alessandro Padovani, MD, PhD;
Daniela Perani, MD
Arch Neurol. 2008;65(6):796-801.
Background Data on white matter changes in corticobasal degeneration syndrome (CBDS) are not yet available, whereas cortical gray matter loss is a feature of this condition. The structural abnormalities related to a key feature of CBDS (limb apraxia) are unknown.
Objectives To measure selective structural changes in early CBDS using diffusion tensor imaging and voxel-based morphometry and to evaluate the structural correlates of limb apraxia.
Design Patient and control group comparison.
Setting Referral center for dementia and movement disorders.
Participants Twenty patients with CBDS and 21 matched control subjects.
Interventions Clinical and standardized neuropsychological evaluations, including assessment of limb apraxia.
Main Outcome Measures Gray and white matter changes in early CBDS.
Results Diffusion tensor imaging revealed decreases in fractional anisotropy in the long frontoparietal connecting tracts, the intraparietal associative fibers, and the corpus callosum. Fractional anisotropy was also reduced in the sensorimotor projections of the cortical hand areas. Voxel-based morphometry showed a prevalent gray matter reduction in the left hemisphere (in the inferior frontal and premotor cortices, parietal operculum, superotemporal gyrus, and hippocampus). The pulvinar, bilaterally, and the right cerebellar cortex also showed atrophy. Limb apraxia correlated with parietal atrophy and with fractional anisotropy reductions in the parietofrontal associative fibers (P < .01). The limb-kinetic component of apraxia correlated with reduction of hand sensorimotor connecting fibers.
Conclusions The present integrative approach to in vivo structural anatomy combines hodologic imaging, describing patterns of white matter connections between cortical areas, with neuropsychological data. This provides new evidence of gray matter and fiber tract abnormalities in early-phase disease and contributes to clarifying the neural basis of apraxia in CBDS.
Author Affiliations: Departments of Neurology (Drs Borroni, Agosti, and Padovani) and Neuroradiology (Dr Gasparotti), University of Brescia, Brescia, Italy; Vita-Salute San Raffaele University, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, and Istituto di Bioimmagini e Fisiologia Molecolare, Consiglio Nazionale delle Ricerche, Milan, Italy (Drs Garibotto and Perani); the Memory Aging Center, Department of Neurology, University of California at San Francisco (Dr Brambati); and Ancelle della Carità Hospital, Cremona, Italy (Dr Bellelli).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
RELATED ARTICLE
This Month in Archives of Neurology
Arch Neurol. 2008;65(6):695-697.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
White Matter Damage in Frontotemporal Lobar Degeneration Spectrum
Agosta et al.
Cereb Cortex 2011;0:bhr288v1-bhr288.
ABSTRACT
| FULL TEXT
Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia
Whitwell et al.
Neurology 2010;74:1279-1287.
ABSTRACT
| FULL TEXT
Association of Ideomotor Apraxia With Frontal Gray Matter Volume Loss in Corticobasal Syndrome
Huey et al.
Arch Neurol 2009;66:1274-1280.
ABSTRACT
| FULL TEXT
Diffusion Tensor Imaging Shows Different Topographic Involvement of the Thalamus in Progressive Supranuclear Palsy and Corticobasal Degeneration
Erbetta et al.
Am. J. Neuroradiol. 2009;30:1482-1487.
ABSTRACT
| FULL TEXT
Tau forms in CSF as a reliable biomarker for progressive supranuclear palsy
Borroni et al.
Neurology 2008;71:1796-1803.
ABSTRACT
| FULL TEXT
|
