This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Diabetes Mellitus  • Genetics, Other  • Review  • Neurogenetics  • Neurology, Other  • Alert me on articles by topic

Charting a Course for Genetic Discovery in Neurological Diseases

John Hardy, PhD; Andrew Singleton, PhD

Arch Neurol. 2008;65(3):319-321.

Whole-genome association analyses have begun to yield confirmed findings for genetic risk variants for complex disease. As the first reports of its application to neurological disease are described, we review this progress, explain the principles of the analysis, and discuss what the future is likely to be in this exciting area.

Author Affiliations: Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London, London, England (Dr Hardy); and Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland (Dr Singleton).