This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Movement Disorders  • Parkinson Disease/ Parkinsonian Disorders  • Alert me on articles by topic  Social Bookmarking   What's this?

Central Role of -Synuclein Oligomers in Neurodegeneration in Parkinson Disease

Aleksey G. Kazantsev, PhD; Alexander M. Kolchinsky, PhD

Arch Neurol. 2008;65(12):1577-1581.

Selective death of nigrostriatal neurons, which leads to Parkinson disease, is explained by misfolding of brain protein -synuclein. Herein, we review the data supporting this concept, propose a scheme of events leading to synuclein-induced neuronal death, and discuss protein deacetylase sirtuins as new potential therapeutic targets involved in this process.

Author Affiliations: Department of Neurology, Harvard Medical School, Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Disease, Charlestown, Massachusetts (Dr Kazantsev); Health Front Line, Ltd, Champaign, Illinois (Dr Kolchinsky).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

This Month in Archives of Neurology
Arch Neurol. 2008;65(12):1564-1565.
FULL TEXT