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Assessment of β-Amyloid in a Frontal Cortical Brain Biopsy Specimen and by Positron Emission Tomography With Carbon 11–Labeled Pittsburgh Compound B
Ville Leinonen, MD, PhD;
Irina Alafuzoff, MD, PhD;
Sargo Aalto, MSc;
Timo Suotunen, BM;
Sakari Savolainen, MD, PhD;
Kjell Någren, PhD;
Tero Tapiola, MD, PhD;
Tuula Pirttilä, MD, PhD;
Jaakko Rinne, MD, PhD;
Juha E. Jääskeläinen, MD, PhD;
Hilkka Soininen, MD, PhD;
Juha O. Rinne, MD, PhD
Arch Neurol. 2008;65(10):1304-1309.
Objective To compare carbon 11–labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) findings in patients with and without Alzheimer disease lesions in frontal cortical biopsy specimens.
Design Cross-sectional study of [11C]PiB PET findings in patients with or without β-amyloid (Aβ) aggregates in frontal cortical biopsy specimens.
Setting Two university hospitals in Finland.
Patients Ten patients who had undergone intraventricular pressure monitoring with a frontal cortical biopsy (evaluated for Aβ aggregates and hyperphosphorylated tau) for suspected normal-pressure hydrocephalus.
Interventions [11C]PiB PET and evaluation for cognitive impairment using a battery of neuropsychological tests.
Main Outcome Measures Immunohistochemical evaluation for Aβ aggregates and hyperphosphorylated tau in the frontal cortical biopsy specimen and [11C]PiB PET.
Results In patients with Aβ aggregates in the frontal cortical biopsy specimen, PET imaging revealed higher [11C]PiB uptake (P < .05) in the frontal, parietal, and lateral temporal cortices and in the striatum as compared with the patients without frontal Aβ deposits.
Conclusions Our study supports the use of noninvasive [11C]PiB PET in the assessment of Aβ deposition in the brain. Large prospective studies are required to verify whether [11C]PiB PET will be a diagnostic aid, particularly in early Alzheimer disease.
Author Affiliations: Departments of Neurosurgery (Drs Leinonen, Savolainen, J. Rinne, and Jääskeläinen) and Neurology (Drs Tapiola, Pirttilä, and Soininen), Kuopio University Hospital and Unit of Pathology and Neurology, Department of Clinical Medicine (Dr Alafuzoff), and Unit of Neurology, Institute of Clinical Medicine (Drs Pirttilä and Soininen), University of Kuopio, Kuopio and Turku PET Centre, University of Turku, Turku (Drs Någren and J. O. Rinne and Messrs Aalto and Suotunen), Finland.
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