This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (18)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Behavioral Neurology  • Movement Disorders  • Parkinson Disease/ Parkinsonian Disorders  • Neurology, Other  • Review  • Drug Therapy  • Drug Therapy, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

Valerie Voon, MD; Susan H. Fox, MD, PhD

Arch Neurol. 2007;64(8):1089-1096.

A range of behaviors presumed to be related to aberrant or excessive dopaminergic medications are being increasingly recognized in Parkinson disease. These behaviors are linked by their incentive- or reward-based and repetitive natures and include pathological gambling, hypersexuality, compulsive shopping, compulsive eating, hobbyism, and compulsive medication use. Such behaviors can have potentially devastating psychosocial consequences and are often hidden. Whether these behaviors are simply related to dopaminergic medications interacting with an underlying individual vulnerability or whether the primary pathological features of Parkinson disease play a role is not known. We reviewed the literature on these behaviors in Parkinson disease, including definitions, epidemiological and potential pathophysiological features, and management. The study of these behaviors allows not only improved clinical management but also greater insight into a biologically mediated complex behavioral model.

Author Affiliations: Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland (Dr Voon); and Department of Psychiatry (Dr Voon) and Division of Neurology, Department of Medicine (Dr Fox), Toronto Western Hospital, Toronto, Ontario, Canada.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Parkinson's disease and dopaminergic therapy--differential effects on movement, reward and cognition
Rowe et al.
Brain 2008;131:2094-2105.
ABSTRACT | FULL TEXT  

Invited Article: Changing concepts in Parkinson disease: Moving beyond the Decade of the Brain
Marras and Lang
Neurology 2008;70:1996-2003.
ABSTRACT | FULL TEXT