 |
 |

Medication-Related Impulse Control and Repetitive Behaviors in Parkinson Disease
Valerie Voon, MD;
Susan H. Fox, MD, PhD
Arch Neurol. 2007;64(8):1089-1096.
A range of behaviors presumed to be related to aberrant or excessive dopaminergic medications are being increasingly recognized in Parkinson disease. These behaviors are linked by their incentive- or reward-based and repetitive natures and include pathological gambling, hypersexuality, compulsive shopping, compulsive eating, hobbyism, and compulsive medication use. Such behaviors can have potentially devastating psychosocial consequences and are often hidden. Whether these behaviors are simply related to dopaminergic medications interacting with an underlying individual vulnerability or whether the primary pathological features of Parkinson disease play a role is not known. We reviewed the literature on these behaviors in Parkinson disease, including definitions, epidemiological and potential pathophysiological features, and management. The study of these behaviors allows not only improved clinical management but also greater insight into a biologically mediated complex behavioral model.
Author Affiliations: Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland (Dr Voon); and Department of Psychiatry (Dr Voon) and Division of Neurology, Department of Medicine (Dr Fox), Toronto Western Hospital, Toronto, Ontario, Canada.
CiteULike Connotea Delicious Digg Facebook Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
 |
Sleep disturbance and impulsive-compulsive behaviours in Parkinson's disease
O'Sullivan et al.
J. Neurol. Neurosurg. Psychiatry 2011;82:620-622.
ABSTRACT
| FULL TEXT
Dopamine agonists and risk: impulse control disorders in Parkinson's; disease
Voon et al.
Brain 2011;134:1438-1446.
ABSTRACT
| FULL TEXT
Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours
O'Sullivan et al.
Brain 2011;134:969-978.
ABSTRACT
| FULL TEXT
Impulse Control Disorders in Parkinson Disease: A Cross-Sectional Study of 3090 Patients
Weintraub et al.
Arch Neurol 2010;67:589-595.
ABSTRACT
| FULL TEXT
Dopamine, Reward, and Frontostriatal Circuitry in Impulse Control Disorders in Parkinson's Disease: Insights from Functional Imaging
Ray and Strafella
Clin EEG Neurosci 2010;41:87-93.
ABSTRACT
| FULL TEXT
Pathological Gambling and Compulsive Eating Associated with Aripiprazole
Roxanas
Aust N Z J Psychiatry 2010;44:291-291.
FULL TEXT
Parkinson's disease and dopaminergic therapy--differential effects on movement, reward and cognition
Rowe et al.
Brain 2008;131:2094-2105.
ABSTRACT
| FULL TEXT
Invited Article: Changing concepts in Parkinson disease: Moving beyond the Decade of the Brain
Marras and Lang
Neurology 2008;70:1996-2003.
ABSTRACT
| FULL TEXT
|