 |
|
Manganese-Induced Parkinsonism Associated With Methcathinone (Ephedrone) Abuse
Rob M. A. de Bie, MD, PhD;
Richard M. Gladstone, MD;
Antonio P. Strafella, MD, PhD;
Ji-Hyun Ko, MSc;
Anthony E. Lang, MD
Arch Neurol. 2007;64(6):886-889.
Background Manganese intoxication may lead to a levodopa-resistant, akinetic-rigid syndrome. A new form of presumed manganese poisoning has been reported in drug-addicted persons from Russia, Ukraine, and Estonia who have intravenously injected self-prepared methcathinone hydrochloride (Ephedrone).
Patient A 36-year-old man from Azerbaijan with hepatitis C and only modest hepatic synthetic dysfunction developed rapid-onset, levodopa-resistant parkinsonism with profound hypophonia.
Conclusion Ephedronic encephalopathy outside the region of the former Soviet Union may become a more widespread public health problem as a result of global travel and the easy availability of the recipe for synthesis of methcathinone on the Internet.
Author Affiliations: Movement Disorders Center, Division of Neurology (Drs de Bie, Strafella, and Lang), PET Imaging Centre, Center of Addiction Mental Health (Dr Strafella), University of Toronto, Toronto, Ontario; Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands (Dr de Bie); and Montreal Neurological Institute, Brain Imaging Centre, McGill University, Montreal, Quebec (Mr Ko). Dr Gladstone is in private practice in Willowdale, Ontario.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
HYPERMANGANESEMIA, HEREDITARY HEMORRHAGIC TELANGIECTASIA, BRAIN ABSCESS: THE HEPATIC CONNECTION
Kumar et al.
Neurology 2008;71:1118-1119.
FULL TEXT
|
