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A New Episodic Ataxia Syndrome With Linkage to Chromosome 19q13
Kevin A. Kerber, MD;
Joanna C. Jen, MD, PhD;
Hane Lee, BS;
Stanley F. Nelson, MD;
Robert W. Baloh, MD
Arch Neurol. 2007;64(5):749-752.
Background Multiple episodic ataxia phenotypes and genotypes have been described.
Objective To describe a new episodic ataxia syndrome.
Design Genomewide linkage analysis with dense single nucleotide polymorphism arrays.
Setting University clinic.
Patients Family with lifelong episodes of ataxia and normal interictal examination results.
Results Suggestive linkage (logarithm of odds score, 3.27) to a 10-centimorgan region on chromosome 19q13.
Conclusion A new dominantly inherited episodic ataxia syndrome is linked to chromosome 19q.
Author Affiliations: Division of Head and Neck Surgery (Dr Baloh), Departments of Neurology (Drs Kerber, Jen, and Baloh), Human Genetics (Ms Lee and Dr Nelson), and Psychiatry and Biobehavioral Sciences (Dr Nelson), UCLA, Los Angeles, Calif. Dr Kerber is now with the Departments of Neurology and Otolaryngology, University of Michigan, Ann Arbor.
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