This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (5)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Aging/ Geriatrics  • Alzheimer Disease  • Movement Disorders  • Parkinson Disease/ Parkinsonian Disorders  • Psychiatry  • Depression  • Alert me on articles by topic  Social Bookmarking   What's this?

Mehdi Tafti, PhD; Norbert B. Ghyselinck, PhD

Arch Neurol. 2007;64(12):1706-1711.

Vitamin A is necessary for normal embryonic development, but its role in the adult brain is poorly understood. Vitamin A derivatives, retinoids, are involved in a complex signaling pathway that regulates gene expression and, in the central nervous system, controls neuronal differentiation and neural tube patterning. Although a major functional implication of retinoic signaling has been repeatedly suggested in synaptic plasticity, learning and memory, sleep, schizophrenia, depression, Parkinson disease, and Alzheimer disease, the targets and the underlying mechanisms in the adult brain remain elusive.

Author Affiliations: Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland (Dr Tafti); and Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U596, Centre National del la Recherche Scientifique Unité Mixte de Recherche 7104, Université Louis Pasteur, Illkirch, France (Dr Ghyselinck).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Vitamin A Deficiency in Rats Induces Anatomic and Metabolic Changes Comparable with Those of Neurodegenerative Disorders
Ghenimi et al.
J. Nutr. 2009;139:696-702.
ABSTRACT | FULL TEXT