You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


Advertisement

ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | RSS | Access Rights | Sign In


  Vol. 64 No. 10, October 2007 TABLE OF CONTENTS
  Online Only
 •  Online First Table of
Contents
  Observation
 •Online Features
 This Article
 •Full text
 •PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on Web of Science (13)
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Topic Collections
 •Neurology
 •Dementias
 •Alert me on articles by topic
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Delicious Add to Digg Add to Facebook Add to Reddit Add to Technorati Add to Twitter What's this?

Potassium Channel Antibody–Associated Encephalopathy Presenting With a Frontotemporal Dementia–like Syndrome

Andrew McKeon, MB, MRCPI; Michael Marnane, MB, MRCPI; Martin O’Connell, FFR, RCSI; John P. Stack, FFR, RCSI; Peter J. Kelly, MD, FRCPI; Timothy Lynch, MD, FRCPI

Arch Neurol. 2007;64(10):1528-1530.

Objective  To describe a patient who presented with features suggestive of frontotemporal dementia (FTD) but with some atypical findings and antibodies to neuronal voltage-gated potassium channels (VGKC-Abs).

Design  Case report.

Setting  Mater Misericordiae University Hospital, Dublin, Ireland.

Results  An 82-year-old man presented with progressive changes in personality, social conduct, and executive function with preservation of memory, deteriorating from baseline to requiring acute hospitalization within 6 months. Transient deterioration (episodic speech arrest) with spontaneous recovery, atypical for frontotemporal dementia, was observed. The patient had an elevated VGKC-Ab titer (2624 pM [normal range, < 100 pM]), elevated protein levels in cerebrospinal fluid, and a negative evaluation for malignancy. Magnetic resonance imaging of brain was normal but [18F]-fluorodeoxyglucose positron emission tomographic imaging revealed bifrontal hypometabolism. A marked and sustained improvement with steroid therapy was observed.

Conclusion  Workup for a potentially reversible autoimmune-mediated encephalopathy, including a VGKC-Ab titer, should be considered in patients presenting with rapidly progressive behavioral and cognitive decline.


Author Affiliations: Departments of Neurology (Drs McKeon, Marnane, Kelly, and Lynch) and Radiology (Messrs O’Connell and Stack), Mater Misericordiae University Hospital, Dublin, Ireland.



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Delicious Delicious   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

VGKC positive autoimmune encephalopathy mimicking dementia
Molloy et al.
BMJ Case Reports 2011;2011:bcr0820114642-bcr0820114642.
ABSTRACT | FULL TEXT  

Sleep Manifestations of Voltage-Gated Potassium Channel Complex Autoimmunity
Cornelius et al.
Arch Neurol 2011;68:733-738.
ABSTRACT | FULL TEXT  

Role of the hippocampus in remembering the past and imagining the future
Squire et al.
Proc. Natl. Acad. Sci. USA 2010;107:19044-19048.
ABSTRACT | FULL TEXT  

Voltage-Gated Potassium Channel Autoimmunity Mimicking Creutzfeldt-Jakob Disease
Geschwind et al.
Arch Neurol 2008;65:1341-1346.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | PHYSICIAN JOBS | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 2007 American Medical Association. All Rights Reserved.