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Greg Allen, PhD; Holly Barnard, MA; Roderick McColl, PhD; Andrea L. Hester, PhD; Julie A. Fields, BA; Myron F. Weiner, MD; Wendy K. Ringe, PhD; Anne M. Lipton, MD, PhD; Matthew Brooker, BS; Elizabeth McDonald, RN; Craig D. Rubin, MD; C. Munro Cullum, PhD

Arch Neurol. 2007;64(10):1482-1487.

Objective  To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease.

Design  Functional connectivity magnetic resonance imaging was used to investigate coherence in the magnetic resonance signal between the hippocampus and all other regions of the brain.

Participants  Eight patients with probable Alzheimer disease and 8 healthy volunteers.

Results  Control subjects showed hippocampal functional connectivity with diffuse cortical, subcortical, and cerebellar sites, while patients demonstrated markedly reduced functional connectivity, including an absence of connectivity with the frontal lobes.

Conclusion  These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.

Author Affiliations: Departments of Psychiatry (Drs Allen, Hester, Weiner, Ringe, Lipton, and Cullum, Mss Barnard and Fields, and Mr Brooker), Radiology (Dr McColl), Neurology (Drs Weiner, Lipton, and Cullum), and Internal Medicine (Ms McDonald and Dr Rubin), University of Texas Southwestern Medical Center, Dallas; School of Behavioral and Brain Sciences, The University of Texas at Dallas (Dr Allen); Department of Psychology, University of Denver, Denver, Colorado (Ms Bernard); Presbyterian Hospital of Dallas (Dr Lipton); and University of North Texas Health Sciences Center, Texas College of Osteopathic Medicine, Fort Worth (Mr Brooker).

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