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A Review of 31 Cases

Irene Favier, MD; Jorine A. van Vliet, MD, PhD; Krista I. Roon, MD, PhD; Ron J. W. Witteveen, MD; Jan J. G. M. Verschuuren, MD, PhD; Michel D. Ferrari, MD, PhD; Joost Haan, MD, PhD

Arch Neurol. 2007;64(1):25-31.

Trigeminal autonomic cephalgias (TACs) include cluster headache, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache with conjunctival injection and tearing. Associated structural lesions may be found, but a causal relationship is often difficult to establish. We sought to identify clinical predictors of underlying structural abnormalities by reviewing previously described and new TAC and TAC-like cases associated with a structural lesion. We found that even typical TACs can be caused by an underlying lesion. Clinical warning signs and symptoms are relatively rare. We recommend neuroimaging in all patients with a TAC or TAC-like syndrome.

Author Affiliations: Department of Neurology, Leiden University Medical Centre, Leiden (Drs Favier, Roon, Verschuuren, Ferrari, and Haan); Department of Neurology, Medical Centre Haaglanden, The Hague (Dr van Vliet); and Department of Neurology, Rijnland Hospital, Leiderdorp (Drs Witteveen and Haan), the Netherlands.

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