 |
|
Twenty-six–Year Change in Total Cholesterol Levels and Incident DementiaThe Honolulu-Asia Aging Study
Robert Stewart, MD;
Lon R. White, MD;
Qian-Li Xue, PhD;
Lenore J. Launer, PhD
Arch Neurol. 2007;64(1):103-107.
Background The relationship between total cholesterol levels and dementia is unclear.
Objective To compare the natural history of change in total cholesterol across 26 years between men who did and did not develop dementia 3 years after the last measurement.
Design, Setting, and Participants In the Honolulu-Asia Aging Study, 1027 Japanese American men had total cholesterol levels assayed on 5 occasions between 1965 and 1993 and were screened for dementia on 2 occasions between 1991 and 1996.
Main Outcome Measure The slope of 26-year change in serum total cholesterol levels was estimated by a repeated-measures analysis and was compared between men with incident dementia (n = 56) and those without dementia (n = 971) at the end of the follow-up period.
Results Cholesterol levels in men with dementia and, in particular, those with Alzheimer disease had declined at least 15 years before the diagnosis and remained lower than cholesterol levels in men without dementia throughout that period. The difference in slopes was robust to adjustment for potential confounding factors, including vascular risk factors, weight change, alcohol intake, and use of lipid-lowering agents.
Conclusion A decline in serum total cholesterol levels may be associated with early stages in the development of dementia.
Author Affiliations: King's College London (Institute of Psychiatry), Section of Epidemiology, London, England (Dr Stewart); Pacific Health Research Institute, Honolulu, Hawaii (Dr White); and The Johns Hopkins Center on Aging and Health (Dr Xue) and Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health (Dr Launer), Baltimore, Md.
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Mild Hypercholesterolemia, Normal Plasma Triglycerides, and Normal Glucose Levels Across Dementia Staging in Alzheimer's Disease: A Clinical Setting-Based Retrospective Study
Ramdane and Daoudi-Gueddah
AM J ALZHEIMERS DIS OTHER DEMEN 2011;26:399-405.
ABSTRACT
Association of Higher Levels of High-Density Lipoprotein Cholesterol in Elderly Individuals and Lower Risk of Late-Onset Alzheimer Disease
Reitz et al.
Arch Neurol 2010;67:1491-1497.
ABSTRACT
| FULL TEXT
The 32-year relationship between cholesterol and dementia from midlife to late life
Mielke et al.
Neurology 2010;75:1888-1895.
ABSTRACT
| FULL TEXT
Midlife cholesterol level and dementia 32 years later: Is there a risk?
Haan
Neurology 2010;75:1862-1863.
FULL TEXT
Cognitive decline precedes late-life longitudinal changes in vascular risk factors
van Vliet et al.
J. Neurol. Neurosurg. Psychiatry 2010;81:1028-1032.
ABSTRACT
| FULL TEXT
Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors
Ritchie et al.
BMJ 2010;341:c3885-c3885.
ABSTRACT
| FULL TEXT
Relationship Between Low Levels of High-Density Lipoprotein Cholesterol and Dementia in the Elderly. The InChianti Study
Zuliani et al.
J Gerontol A Biol Sci Med Sci 2010;65A:559-564.
ABSTRACT
| FULL TEXT
History of coronary heart disease and cognitive performance in midlife: the Whitehall II study
Singh-Manoux et al.
Eur Heart J 2008;29:2100-2107.
ABSTRACT
| FULL TEXT
Low HDL Cholesterol Is a Risk Factor for Deficit and Decline in Memory in Midlife: The Whitehall II Study
Singh-Manoux et al.
Arterioscler. Thromb. Vasc. Bio. 2008;28:1556-1562.
ABSTRACT
| FULL TEXT
Statins Reduce Amyloid-beta Production through Inhibition of Protein Isoprenylation
Ostrowski et al.
J. Biol. Chem. 2007;282:26832-26844.
ABSTRACT
| FULL TEXT
The metabolic syndrome is associated with decelerated cognitive decline in the oldest old
van den Berg et al.
Neurology 2007;69:979-985.
ABSTRACT
| FULL TEXT
|
