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Predicting Progression to Multiple Sclerosis

Clare Fraser, MBBS; Alexander Klistorner, PhD; Stuart Graham, MBBS, FRANZCO, PhD; Raymond Garrick, MBBS, FRACP; Francis Billson, MBBS, FRANZCO; John Grigg, MBBS, FRANZCO

Arch Neurol. 2006;63:847-850.

Objective  To monitor the difference in conversion rates to multiple sclerosis (MS) in 46 patients with optic neuritis between patients with multifocal visual evoked potential latency delay and those with normal latency.

Design  Prospective case series.

Setting  Metropolitan neuro-ophthalmology clinic.

Participants  Forty-six patients with optic neuritis who did not have a diagnosis of MS on enrollment in the study.

Main Outcome Measures  Conversion to MS according to the McDonald criteria.

Results  Analysis revealed that only 22 subjects had multifocal visual evoked potential latency delay. Over 1 year, 36.4% of patients with optic neuritis with latency delays progressed clinically to MS compared with 0% of those with normal latencies (P = .03, ²).

Conclusion  This may indicate that multifocal visual evoked potential latency delay can assist in predicting progression to future MS.

Author Affiliations: Save Sight Institute, Sydney, Australia (Drs Fraser, Klistorner, Graham, Billson, and Grigg); and St Vincent's Hospital, Sydney (Dr Garrick).

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