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Back in Fashion With a Little Help From Genetics

Miratul M. K. Muqit, MRCP; Sonia Gandhi, MRCP; Nicholas W. Wood, PhD, FRCP, FMedSci

Arch Neurol. 2006;63:649-654.

Parkinson disease is a devastating neurodegenerative disorder with no known cure. Impairment in mitochondrial dysfunction is thought to play a major role in the pathogenesis. Recent genetic advances suggest that mitochondrial dysfunction may be the primary defect. Drugs that target the mitochondria may therefore represent the best hope for disease-modifying therapies in Parkinson disease.

Author Affiliations: Department of Molecular Neuroscience, Institute of Neurology, University College London, London, England.

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