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Magnetoencephalographic Parietal Dipole Density in Mild Cognitive Impairment

Preliminary Results of a Method to Estimate the Risk of Developing Alzheimer Disease

Alberto Fernández, PhD; Agustín Turrero, PhD; Pilar Zuluaga, PhD; Pedro Gil, MD, PhD; Fernando Maestú, PhD; Pablo Campo, PhD; Tomás Ortiz, MD, PhD

Arch Neurol. 2006;63:427-430.

Background  Subjects with mild cognitive impairment (MCI) are at a higher risk of experiencing Alzheimer disease (AD). Magnetoencephalographic temporoparietal dipole densities of low-frequency activity are good predictors of individuals' cognitive status, and might be a useful tool to investigate the conversion from MCI to AD.

Objective  To investigate the role of low-frequency dipole densities as predictors of the risk of developing AD.

Design  Whole-head magnetoencephalographic recordings were obtained from 19 probable AD patients, 17 MCI patients, and 17 healthy control subjects. The generators of focal magnetic slow waves were located using a single moving dipole model.

Results  Left parietal dipole density permitted a reliable classification of AD and MCI patients. The MCI patients were divided into 2 groups based on the median left parietal dipole density, and were followed up for 2 years. The estimated relative risk of conversion to AD was increased by 350% in those MCI patients with high left parietal dipole density scores.

Conclusions  Results confirmed the important role of parietal dipole density in the evaluation of AD and MCI. A magnetoencephalographic-based assessment of AD and MCI patients might be considered a useful clinical test in the near future.

Author Affiliations: Centro MEG Dr Pérez Modrego (Drs Fernández, Maestú, Campo, and Ortiz) and Departamento de Bioestadística e Investigación Operativa (Drs Turrero and Zuluaga), Universidad Complutense de Madrid; and Servicio de Geriatría, Hospital Clínico Universitario San Carlos de Madrid (Dr Gil), Madrid, Spain.

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