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Magnetoencephalographic Parietal  Dipole Density in Mild Cognitive Impairment
Preliminary Results of a Method to Estimate the Risk of Developing Alzheimer Disease
Alberto Fernández, PhD;
Agustín Turrero, PhD;
Pilar Zuluaga, PhD;
Pedro Gil, MD, PhD;
Fernando Maestú, PhD;
Pablo Campo, PhD;
Tomás Ortiz, MD, PhD
Arch Neurol. 2006;63:427-430.
Background Subjects with mild cognitive impairment (MCI) are at a higher risk of experiencing Alzheimer disease (AD). Magnetoencephalographic temporoparietal dipole densities of low-frequency activity are good predictors of individuals' cognitive status, and might be a useful tool to investigate the conversion from MCI to AD.
Objective To investigate the role of low-frequency dipole densities as predictors of the risk of developing AD.
Design Whole-head magnetoencephalographic recordings were obtained from 19 probable AD patients, 17 MCI patients, and 17 healthy control subjects. The generators of focal magnetic slow waves were located using a single moving dipole model.
Results Left parietal  dipole density permitted a reliable classification of AD and MCI patients. The MCI patients were divided into 2 groups based on the median left parietal dipole density, and were followed up for 2 years. The estimated relative risk of conversion to AD was increased by 350% in those MCI patients with high left parietal dipole density scores.
Conclusions Results confirmed the important role of parietal dipole density in the evaluation of AD and MCI. A magnetoencephalographic-based assessment of AD and MCI patients might be considered a useful clinical test in the near future.
Author Affiliations: Centro MEG Dr Pérez Modrego (Drs Fernández, Maestú, Campo, and Ortiz) and Departamento de Bioestadística e Investigación Operativa (Drs Turrero and Zuluaga), Universidad Complutense de Madrid; and Servicio de Geriatría, Hospital Clínico Universitario San Carlos de Madrid (Dr Gil), Madrid, Spain.
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