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Cardiac and Pulmonary Investigations in Bethlem Myopathy
Anneke J. van der Kooi, MD, PhD;
Willem G. de Voogt, MD;
Enrico Bertini, MD;
Luciano Merlini, MD;
F. Beril Talim, MD;
Rabah Ben Yaou, MD;
Andoni Urtziberea, MD;
Marianne de Visser, MD
Arch Neurol. 2006;63:1617-1621.
Background Bethlem myopathy is considered a relatively mild neuromuscular disorder without significant cardiac and respiratory involvement.
Objective To investigate cardiac and respiratory involvement in Bethlem myopathy.
Design Cross-sectional study.
Setting University hospitals.
Patients Fifty patients with Bethlem myopathy from 26 families.
Interventions Cardiac examinations, including electrocardiography and echocardiography (n = 37) and pulmonary investigations (n = 43). Holter monitoring was performed in 16 patients.
Main Outcome Measures Cardiac and respiratory abnormalities.
Results Several cardiac abnormalities were found that were considered unrelated to the muscular disorder. Seven (16%) of 43 patients had a forced vital capacity less than 70% of the predicted value. One of 2 patients with a forced vital capacity less than 50% was also receiving respiratory support. All patients with compromised respiratory function were still ambulatory, and we found no significant correlation between the severity of arm weakness and the severity of respiratory muscle involvement.
Conclusions There is no evidence of cardiac involvement in Bethlem myopathy. Respiratory failure is part of the clinical spectrum and can occur in ambulatory patients.
Author Affiliations: Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands (Drs van der Kooi and de Visser); Department of Cardiology, St Lucas Andreas Hospital, Amsterdam (Dr de Voogt); Unit of Molecular Medicine, Department of Laboratory Medicine, Bambino Gesù Hospital, Rome, Italy (Dr Bertini); Neuromuscular Unit, Division of Medical Genetics, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy (Dr Merlini); Department of Pediatrics, Hacettepe University, Ankara, Turkey (Dr Talim); and Institut de Myologie, G. H. Pitié Salpetrière, Paris, France (Drs Ben Yaou and Urtziberea).
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Cardiac Involvement in Bethlem Myopathy
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