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Karina Stavitsky, BS; Adam M. Brickman, PhD; Nikolaos Scarmeas, MD; Rebecca L. Torgan, BS; Ming-Xin Tang, PhD; Marilyn Albert, PhD; Jason Brandt, PhD; Deborah Blacker, MD; Yaakov Stern, PhD

Arch Neurol. 2006;63:1450-1456.

Background  Although dementia with Lewy bodies (DLB) may be one of most common forms of dementia, relatively little is known about its cognitive and functional course.

Objective  To compare change over time in general cognitive status, memory test performance, psychiatric symptoms, neurological signs, and functional abilities in patients with probable DLB and probable Alzheimer disease (AD).

Design  Twenty-eight patients who met diagnostic criteria for DLB were recruited into the study from 3 sites. Patients with AD (n = 55) were selected from a larger cohort and matched 2 to 1 to the patients with DLB on age and baseline global cognitive status. Patients were followed up at 6-month intervals for an average of 6.2 visits and assessed at each visit with tests of global cognitive functioning and verbal learning and memory and measures of psychiatric, neurological, and functional status.

Results  At the baseline evaluation, patients with DLB performed more poorly on a measure of constructional praxis and all measures of functional status. They also had more severe psychiatric symptoms and neurological signs than the AD group. Despite these initial differences, generalized estimating equations applied to regression analyses with repeated measures determined that the only difference between the 2 groups in change in cognitive test performance was on a measure of recognition memory; patients with AD declined, while patients with DLB remained relatively stable. Patients with DLB had relatively stable behavioral symptoms and visual illusions, whereas patients with AD had a significant increase in these symptoms over time. Neurological and functional changes over time were similar in the 2 groups.

Conclusions  Both baseline and longitudinal differences between patients with DLB and patients with AD were noted; these have implications for clinical diagnosis and treatment.

Author Affiliations: Gertrude H. Sergievsky Center (Mss Stavitsky and Torgan and Drs Brickman, Scarmeas, Tang, and Stern) and Department of Neurology (Drs Scarmeas and Stern), Columbia University Medical Center, New York, NY; Departments of Neurology (Dr Albert) and Psychiatry and Behavioral Sciences (Dr Brandt), Johns Hopkins University, Baltimore, Md; and Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (Dr Blacker).

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