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Measurements of the Amygdala and Hippocampus in Pathologically Confirmed Alzheimer Disease and Frontotemporal Lobar Degeneration
Josephine Barnes, MA;
Jennifer L. Whitwell, PhD;
Chris Frost, MA, DipStat;
Keith A. Josephs, MST, MD;
Martin Rossor, MD, FRCP;
Nick C. Fox, MD, FRCP
Arch Neurol. 2006;63:1434-1439.
Background Differentiating between Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD) can be difficult, particularly in the earliest stages of the diseases. Patterns of atrophy on magnetic resonance imaging may help distinguish these diseases and aid diagnosis.
Objective To assess the diagnostic utility of magnetic resonance imaging–derived amygdala and hippocampal volumes from patients with pathologically proved AD and FTLD.
Design Cross-sectional volumetric magnetic resonance imaging study of the hippocampus and amygdala.
Setting Specialist cognitive disorders clinic.
Subjects Thirty-seven subjects, including 10 patients with pathologically proved AD, 17 patients with pathologically proved FTLD, and 10 age-matched control subjects.
Main Outcome Measures Hippocampal and amygdala volumes.
Results Geometric mean amygdala and hippocampal volumes were, respectively, 15.0% (95% confidence interval [CI], 4.2%-24.5%) and 16.4% (95% CI, 5.9%-25.6%) lower in the AD than in the control group. In FTLD, the equivalent differences were 43.1% (95% CI, 31.9%-52.6%) in the amygdala and 36.1% (95% CI, 27.5%-43.7%) in the hippocampus. Volumes were significantly lower in the FTLD than in the AD group (P<.01 in both regions). Within the FTLD clinical subgroups, there was evidence of a difference in pattern of atrophy with greater asymmetry (left smaller than right) in semantic dementia compared with frontal variant FTLD (P<.001). On average, the left hippocampus was 14% smaller in semantic dementia than in frontal variant FTLD, whereas the right hippocampus was 37% larger. On average, the left amygdala was 39% smaller in semantic dementia than in frontal variant FTLD, whereas the right amygdala was only 1% smaller.
Conclusions Hippocampal atrophy is not specific to AD or FTLD. However, severe or asymmetrical amygdala atrophy should suggest FTLD. Atrophy patterns follow clinical syndromes rather than pathology.
Author Affiliations: Dementia Research Centre, University College London, Institute of Neurology (Ms Barnes; Drs Whitwell, Rossor, and Fox; and Mr Frost), Medical Statistics Unit, London School of Hygiene and Tropical Medicine (Mr Frost), Department of Clinical Neurology, National Hospital for Neurology and Neurosurgery (Drs Rossor and Fox), and Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London (Dr Rossor), London, England; and Departments of Diagnostic Radiology (Dr Whitwell) and Neurology (Dr Josephs), Mayo Clinic, Rochester, Minn.
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