This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (27)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Dementias  • Radiologic Imaging  • Magnetic Resonance Imaging  • Alert me on articles by topic  Social Bookmarking   What's this?

Jennifer L. Whitwell, BA; Keith A. Josephs, MST, MD; Martin N. Rossor, MD, FRCP; John M. Stevens, DRACR, FRCR; Tamas Revesz, MD; Janice L. Holton, MB, ChB, PhD; Safa Al-Sarraj, MSc, FRCPath; Alison K. Godbolt, MA, MRCP; Nick C. Fox, MD, MRCP; Jason D. Warren, FRACP

Arch Neurol. 2005;62:1402-1408.

Background  The pathologic substrates of frontotemporal dementia (FTD) are difficult to predict in vivo.

Objective  To determine whether different pathologic substrates of FTD have distinct patterns of regional atrophy on magnetic resonance imaging (MRI).

Design  Retrospective case study.

Setting  The Institute of Neurology, University College London, and the Institute of Psychiatry, King’s College London.

Patients  Twenty-one cases of FTD selected on pathologic grounds (9 with ubiquitin-positive [tau- and -synuclein–negative] inclusions [FTD-U], 7 with Pick disease [PiD], and 5 with familial FTD with tau exon 10+16 mutations [tau exon 10+16]) and 20 healthy controls were studied.

Main Outcome Measures  Patterns of gray matter atrophy in each group as assessed by voxel-based morphometry (VBM) and a blinded visual assessment of each MRI study.

Results  All pathologic substrates were associated with atrophy that involved the inferior and medial temporal and inferior frontal lobes. Additionally, specific VBM signatures were identified for each subgroup: FTD-U was associated with asymmetric (left > right) temporal lobe atrophy, PiD was associated with severe dorsolateral bifrontal atrophy, and tau exon 10+16 was associated with asymmetric (right > left) medial temporal lobe atrophy. The VBM findings were supported by blinded visual assessment.

Conclusion  These findings suggest that MRI patterns of regional gray matter atrophy constitute signatures of tissue pathology in FTD.

Author Affiliations: Dementia Research Centre, Institute of Neurology, University College London, London, England (Ms Whitwell and Drs Josephs, Rossor, Godbolt, Fox, and Warren); Department of Neurology, Mayo Clinic, Rochester, Minn (Dr Josephs); Division of Neuroscience and Psychological Medicine, Imperial College, London (Dr Rossor); Departments of Neuroradiology (Dr Stevens) and Molecular Neuroscience (Drs Revesz and Holton), Institute of Neurology, London; and Department of Neuropathology, Institute of Psychiatry, King’s College London, London (Dr Al-Sarraj).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Distinct anatomical subtypes of the behavioural variant of frontotemporal dementia: a cluster analysis study
Whitwell et al.
Brain 2009;132:2932-2946.
ABSTRACT | FULL TEXT  

Atrophy patterns in IVS10+16, IVS10+3, N279K, S305N, P301L, and V337M MAPT mutations
Whitwell et al.
Neurology 2009;73:1058-1065.
ABSTRACT | FULL TEXT  

Voxel-Based Morphometry: An Automated Technique for Assessing Structural Changes in the Brain
Whitwell
J. Neurosci. 2009;29:9661-9664.
FULL TEXT  

Atrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration
Pereira et al.
Neurology 2009;72:1653-1660.
ABSTRACT | FULL TEXT  

Voxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN
Whitwell et al.
Neurology 2009;72:813-820.
ABSTRACT | FULL TEXT  

Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype
Josephs et al.
Neurology 2008;70:1850-1857.
ABSTRACT | FULL TEXT  

Distinct MRI Atrophy Patterns in Autopsy-Proven Alzheimer's Disease and Frontotemporal Lobar Degeneration
Rabinovici et al.
AM J ALZHEIMERS DIS OTHER DEMEN 2008;22:474-488.
ABSTRACT  

The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family
Spina et al.
Brain 2008;131:72-89.
ABSTRACT | FULL TEXT  

Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration
Kim et al.
J. Neurol. Neurosurg. Psychiatry 2007;78:1375-1378.
ABSTRACT | FULL TEXT  

Clinical Features of Pathologic Subtypes of Behavioral-Variant Frontotemporal Dementia
Hu et al.
Arch Neurol 2007;64:1611-1616.
ABSTRACT | FULL TEXT  

Rates of cerebral atrophy differ in different degenerative pathologies
Whitwell et al.
Brain 2007;130:1148-1158.
ABSTRACT | FULL TEXT  

Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia
Du et al.
Brain 2007;130:1159-1166.
ABSTRACT | FULL TEXT  

Voxel-Based Morphometry in Frontotemporal Lobar Degeneration With Ubiquitin-Positive Inclusions With and Without Progranulin Mutations
Whitwell et al.
Arch Neurol 2007;64:371-376.
ABSTRACT | FULL TEXT  

Whole-Brain and Regional Brain Atrophy in Amyotrophic Lateral Sclerosis
Mezzapesa et al.
Am. J. Neuroradiol. 2007;28:255-259.
ABSTRACT | FULL TEXT  

Evidence of White Matter Changes on Diffusion Tensor Imaging in Frontotemporal Dementia
Borroni et al.
Arch Neurol 2007;64:246-251.
ABSTRACT | FULL TEXT  

Frontotemporal Lobar Degeneration Without Lobar Atrophy
Josephs et al.
Arch Neurol 2006;63:1632-1638.
ABSTRACT | FULL TEXT  

Measurements of the Amygdala and Hippocampus in Pathologically Confirmed Alzheimer Disease and Frontotemporal Lobar Degeneration.
Barnes et al.
Arch Neurol 2006;63:1434-1439.
ABSTRACT | FULL TEXT  

Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration
Whitwell et al.
Neurology 2006;66:102-104.
ABSTRACT | FULL TEXT