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Insular Cortex Infarction in Acute Middle Cerebral Artery Territory Stroke
Predictor of Stroke Severity and Vascular Lesion
John N. Fink, FRACP;
Magdy H. Selim, MD;
Sandeep Kumar, MD;
Barbara Voetsch, MD, PhD;
Wing Chi Fong, MRCP;
Louis R. Caplan, MD
Arch Neurol. 2005;62:1081-1085.
Background Insula infarction is an early computed tomographic sign of middle cerebral artery (MCA) territory stroke and may affect cardiovascular autonomic function.
Objective To determine insula involvement in MCA territory infarction and its relationship with infarcts in the remainder of the MCA territory, stroke severity, and clinically relevant cardiovascular conditions.
Design Case series (August 1, 1997, to June 30, 2000).
Setting Academic stroke center.
Patients A total of 150 consecutive patients with nonlacunar MCA territory stroke who underwent magnetic resonance imaging within 48 hours of stroke onset.
Main Outcome Measures Association of insula infarction with the National Institutes of Health Stroke Scale (NIHSS) score, location of vascular occlusion, and cardiovascular events.
Results Insular lesions were present in 72 patients (48%); 34 (23%) had major insular lesions and 38 (25%) had minor lesions. Insula infarction was associated with lenticulostriate territory infarction (46% vs 14%; P<.001), more than one third of MCA territory infarction (35% vs 3%; P<.001), higher NIHSS score (13.5 vs 6; P<.001), and proximal vascular occlusion detected on magnetic resonance angiography. These associations were strongest for patients with major insular lesions. Clinically significant new arrhythmia was present in 15 of 72 with insula infarction (13 atrial fibrillations) and 4 of 78 without (P = .06). Insula infarction was associated with lower diastolic blood pressure at admission but was not associated with pulse rate, QTc interval, myocardial infarction, or sudden death.
Conclusions The insular cortex is involved in almost half of patients with nonlacunar ischemic MCA territory strokes. Major insula involvement is associated with large MCA territory infarcts, proximal MCA occlusions, and greater stroke severity. Insula infarction was not a predictor of clinically significant acute cardiovascular events during hospital stay in our patients.
Author Affiliations: Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand (Dr Fink); Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School (Drs Selim and Caplan), and Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine (Dr Voetsch), Boston, Mass; South Shore Hospital, Weymouth, Mass (Dr Kumar); and Department of Medicine, Queen Elizabeth Hospital, Hong Kong SAR (Dr Fong).
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