Anti-MuSK Myasthenia Gravis Presenting With Purely Ocular Findings
James B. Caress, MD;
Christopher H. Hunt, MD;
Sat Dev Batish, PhD
Arch Neurol. 2005;62:1002-1003.
Background Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) have been found in approximately 40% of patients with generalized myasthenia gravis who are seronegative for the antiacetylcholine receptor antibody. Many of the patients with anti-MuSK antibodies have prominent oculobulbar symptoms or weakness of the neck and respiratory muscles, but patients with ocular myasthenia have not been described.
Objective To report a case of ocular myasthenia due to anti-MuSK antibodies.
Patient A young woman with ocular myasthenia and antibodies to MuSK.
Results Anti-MuSK antibody was detected by radioimmunoassay using highly purified MuSK recombinant antigen.
Conclusion Ocular myasthenia gravis is a presentation of the anti-MuSK antibody syndrome.
Author Affiliations: Department of Neurology, Wake Forest University School of Medicine (Dr Caress), and Winston Neurology (Dr Hunt), Winston-Salem, NC; and Athena Diagnostics Inc, Worcester Mass (Dr Batish).
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