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Brachial Amyotrophic Diplegia in a Patient With Human Immunodeficiency Virus Infection
Widening the Spectrum of Motor Neuron Diseases Occurring With the Human Immunodeficiency Virus
Joseph R. Berger, MD;
Patricio S. Espinosa, MD, MPH;
John Kissel, MD
Arch Neurol. 2005;62:817-823.
Although amyotrophic lateral sclerosis and progressive spinal muscular atrophy have been recognized to occur in association with human immunodeficiency virus infection, to our knowledge, brachial amyotrophic diplegia, a form of segmental motor neuron disease, has not been previously reported. Brachial amyotrophic diplegia results in severe lower motor neuron weakness and atrophy of the upper extremities in the absence of bulbar or lower extremity involvement, pyramidal features, bowel and bladder incontinence, and sensory loss. We describe a human immunodeficiency virus–seropositive man without severe immunosuppression or prior AIDS-defining illnesses who had brachial amyotrophic diplegia. This disorder may represent one end of a spectrum of motor neuron diseases occurring with this retrovirus infection.
Author Affiliations: Departments of Neurology (Drs Berger and Espinosa) and Internal Medicine (Dr Berger), University of Kentucky College of Medicine, Lexington; and Department of Neurology, Ohio State University, Columbus (Dr Kissel).
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