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Dementia Subtypes in China
Prevalence in Beijing, Xian, Shanghai, and Chengdu
Zhen-Xin Zhang, MD;
Gwendolyn E. P. Zahner, PhD;
Gustavo C. Román, MD;
Jun Liu, PhD;
Zhen Hong, MD;
Qiu-Ming Qu, MD;
Xie-He Liu, MD;
Xiao-Jun Zhang, MD;
Bing Zhou, MD;
Cheng-Bing Wu, MD;
Mao-Ni Tang, MD;
Xia Hong, MD;
Hui Li, MD, MPH
Arch Neurol. 2005;62:447-453.
Background Prevalences of Alzheimer disease (AD) and vascular dementia (VaD) in China reportedly differ from those in Western countries.
Objective To estimate prevalence of AD and VaD in 4 regions of China.
Design Cross-sectional, population-based prevalence survey with a stratified, multistage cluster sampling design.
Setting Rural (n = 99) and urbanized (n = 71) communities of Beijing, Xian, Shanghai, and Chengdu.
Participants A sample of 34 807 community residents (94% of those eligible) 55 years or older.
Main Outcome Measures Participants were screened with the Chinese Mini-Mental State Examination. Those who screened positive (n = 3950) underwent a standardized diagnostic workup. Screening sensitivity was assessed in a 3.3% random sample (n = 1008 of the 30 857 who passed the screening). Diagnoses of AD and VaD were made according to National Institute of Neurological and Communicative Diseases and Stroke–Alzheimer Disease and Related Disorders Association and National Institute of Neurological Disorders and Stroke–Association Internationale pour la Recherche et l’Enseignement en Neurosciences criteria, respectively. Final diagnoses were made after a 6-month confirmation interval.
Results We identified 732 AD cases and 295 VaD cases. Prevalence in persons 65 years or older was 3.5% (95% confidence interval, 3.0%-3.9%) for AD and 1.1% (95% confidence interval, 0.9%-1.1%) for VaD. After post hoc correction for negative screening errors, prevalence increased to 4.8% for AD and remained at 1.1% for VaD.
Conclusion Prevalence of dementia subtypes in China is comparable with that in Western countries.
Author Affiliations: Departments of Clinical Epidemiology (Drs Z.-X. Zhang and X. Hong) and Neurology (Drs Z.-X. Zhang and X. Hong), Peking Union Medical College Hospital, and Department of Epidemiology, Peking Union Medical College (Dr Li), Chinese Academy of Medical Sciences, Beijing, China; Health, Social and Economics Research Division (Dr Zahner) and Statistics Research Division (Dr J. Liu), Research Triangle Institute, Research Triangle Park, NC; Department of Medicine/Neurology, University of Texas Health Science Center, San Antonio (Dr Román); Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China (Drs Z. Hong and B. Zhou); Department of Neurology, The First Hospital, Xian University, Xian, China (Drs Qu and Wu), Department of Psychiatry, The First Hospital, Huaxi Medical College, Chengdu, China (Drs X.-H. Liu and Tang); and Department of Neurology, Tongren Hospital, Beijing, China (Dr X. J. Zhang).
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