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A Report From the AAASPS

Sean Ruland, DO; Elena Hung, MS; Dejuran Richardson, PhD; Subhasree Misra, MD; Philip B. Gorelick, MD, MPH; for the African American Antiplatelet Stroke Prevention Study Investigators (AAASPS)

Arch Neurol. 2005;62:386-390.

Background  The rates of obesity and the metabolic syndrome and the impact on traditional vascular risk factors in African American stroke survivors are unknown.

Objective  To describe the relationships between body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters) and hypertension, dyslipidemia, and diabetes mellitus.

Design  We classified 1711 subjects as underweight (BMI, <18.5), normal (BMI, 18.5-24.9), overweight (BMI, 25.0-29.9), or obesity class 1 (BMI, 30.0-34.9), 2 (BMI, 35.0-39.9), or 3 (BMI, >40.0). We compared the proportions with hypertension, dyslipidemia, and diabetes mellitus and control of these factors by clinical history and results of physical examination and laboratory analysis across BMI groups.

Setting  Multicentered clinical trial.

Patients  African American subjects with previous ischemic stroke.

Main Outcome Measures  Rates of obesity and the metabolic syndrome, odds ratios (ORs) of associated vascular risk factors at baseline, and relationship to longitudinal risk factor control.

Results  Overall, 76% were overweight or obese (70% of men and 81% of women). Hypertension, dyslipidemia, and diabetes mellitus were all present in 43.3% of men and 29.1% of women with obesity class 3. The ORs for having the metabolic syndrome were 2.14 (95% confidence interval [CI], 1.52-3.01) for class 1, 1.92 (95% CI, 1.26-2.91) for class 2, and 1.98 (95% CI, 1.27-3.09) for class 3 obesity. In addition, increasing BMI was negatively associated with systolic (P<.001) and diastolic (P<.001) blood pressure and glycemic control (P<.001).

Conclusion  Our analysis of the data from the African American Antiplatelet Stroke Prevention Study supports the association of increasing risk factor profiles with increasing weight in African American stroke survivors.

Author Affiliations: Department of Neurology and Rehabilitation, University of Illinois at Chicago (Drs Ruland, Richardson, and Gorelick and Ms Hung); Department of Mathematics and Computer Science, Lake Forest College, Lake Forest, Ill (Dr Richardson); and Department of Neurology, Rush University Medical Center, Chicago (Dr Misra).
Group Information: A complete list of the African American Antiplatelet Stroke Prevention Study Investigators was published previously (JAMA. 2003;289:2947-2957).

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