This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (4)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Genetics, Other  • Neurogenetics  • Alert me on articles by topic

Hassan M. Fathallah-Shaykh, MD

Arch Neurol. 2005;62:233-236.

Oxygen is required for respiration and the energetic processes that enable aerobic life. Reactive oxygen species and free radicals, by-products of oxygen use, cause DNA damage and induce endoplasmic reticulum (ER) stress and apoptosis. However, rapidly multiplying cancer cells are resistant to ER and oxidative stress–induced apoptosis. The present article reports the results of highly specific genome-scale expression discovery used to identify genes differentially expressed in cultured glioma cells vs normal brain tissue. The discovered states of expression reveal a cohesive molecular system that protects rapidly growing glioma cells from ER and oxidative stress–induced apoptosis.

Author Affiliation: Department of Neurological Sciences, Section of Neuro-Oncology, Rush University Medical Center, Chicago, Ill.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Noise and rank-dependent geometrical filter improves sensitivity of highly specific discovery by microarrays
Fathallah-Shaykh
Bioinformatics 2005;21:4255-4262.
ABSTRACT | FULL TEXT  

Microarrays: Applications and Pitfalls
Fathallah-Shaykh
Arch Neurol 2005;62:1669-1672.
ABSTRACT | FULL TEXT