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Requirements for Medication Development

Floyd E. Bloom, MD; John F. Reilly, PhD; Jeff M. Redwine, PhD; Chi-Cheng Wu, PhD; Warren G. Young, PhD; John H. Morrison, PhD

Arch Neurol. 2005;62:185-187.

Central nervous system diseases constitute a major target for drug development. Transgenic mouse models, in which genes identified in familial forms of human brain diseases are expressed in mouse neurons and glia, offer opportunities to detect and follow pathologic progression and provide potential biomarkers by which to assess therapeutic interventions. Evidence for Alzheimer disease suggests some starting requirements for the experimental data that could enhance the likelihood of developing medications in these mouse models that would also be effective in humans.

Author Affiliations: Neurome Inc, La Jolla, Calif (Drs Bloom, Reilly, Redwine, Wu, and Young); and Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY (Dr Morrison).

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