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A Case Report and Discussion of Pathophysiology

Andrew W. Tarulli, MD; Chun Lim, MD, PhD; Jonathan D. Bui, MD, PhD; Clifford B. Saper, MD, PhD; Michael P. Alexander, MD

Arch Neurol. 2005;62:1632-1634.

Background  Central neurogenic hyperventilation is a rare condition with poorly understood pathophysiology.

Objective  To describe a patient with central neurogenic hyperventilation caused by an infiltrative brainstem lymphoma.

Conclusion  Based on analysis of this patient and other case reports, we propose that central neurogenic hyperventilation is uniquely the result of infiltrative tumors that stimulate pontine respiratory centers and central chemoreceptors.

Author Affiliations: Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Mass.

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