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A Historical Analysis

Egilius L. H. Spierings, MD, PhD

Arch Neurol. 2004;61:794-799.

A historical analysis is presented of insights into the pathogenetic mechanisms related to the migraine aura and headache and how the mechanisms connect. In the traditional sequential concept, advanced through the work of Edward Liveing, MD, Harold G. Wolff, MD, and others, the mechanisms are considered causally connected. A noncausal, parallel concept has been proposed as well and is considered in light of the results of recent animal experimental studies.

From the Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.

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