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Neuropsychological Correlates of Basal Ganglia and Medial Temporal Lobe NAA/Cho Reductions in Traumatic Brain Injury
Mar Ariza, MS;
Carme Junqué, PhD;
Maria Mataró, PhD;
Maria A. Poca, MD, PhD;
Núria Bargalló, MD;
Miren Olondo, MD;
Joan Sahuquillo, MD, PhD
Arch Neurol. 2004;61:541-544.
Background Proton magnetic resonance spectroscopy can assess neurochemical sequelae in traumatic brain injury. Metabolic abnormalities are present in the acute or subacute period in patients with traumatic brain injury and correlate with outcome on clinical scales.
Objective To investigate the use of proton magnetic resonance spectroscopy in detecting possible gray subcortical neurochemical impairments and their relationship with neuropsychological performance.
Design Group comparisons and correlations of brain metabolites with clinical and neuropsychological variables.
Patients and Methods Metabolite concentrations were acquired from voxels localized to the basal ganglia and medial temporal region in 20 patients with long-term moderate and severe traumatic brain injury and 20 matched control subjects. Both groups underwent neuropsychological assessment.
Results N-acetylaspartate–choline-containing compounds ratios were decreased in patients in the basal ganglia (t = –3.28, P = .002) and medial temporal region (t = –3.52, P = .001). The basal ganglia ratio correlated to measures of speed, motor scanning, and attention.
Conclusion Patients with long-term TBI present a regional correlation pattern that may help identify the neurological basis of cognitive sequelae in traumatic brain injury.
From the Department of Psychiatry and Clinical Psychobiology, University of Barcelona (Mrs Ariza and Drs Junqué and Mataró); Institut d'Investigacions Biomediques August Pi i Sunyer (Dr Junqué), Department of Neurosurgery, Vall d'Hebron University Hospital (Drs Poca and Sahuquillo), and the Department of Radiology, Centre de Diagnòstic per Imatge, Hospital Clinic de Barcelona (Dr Bargalló and Olondo), Barcelona, Spain.
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