 |
|
Correlation Between Antemortem Magnetic Resonance Imaging Findings and Pathologically Confirmed Corticobasal Degeneration
Keith A. Josephs, MST, MD;
David F. Tang-Wai, MD, CM;
Steven D. Edland, PhD;
David S. Knopman, MD;
Dennis W. Dickson, MD;
Joseph E. Parisi, MD;
Ronald C. Petersen, PhD, MD;
Clifford R. Jack, Jr, MD;
Bradley F. Boeve, MD
Arch Neurol. 2004;61:1881-1884.
Background Slowly progressive asymmetric parkinsonism and cortical dysfunction clinically characterize corticobasal syndrome (CBS). Various pathologic findings, including corticobasal degeneration (CBD), progressive supranuclear palsy, and frontotemporal degenerations, underlie CBS.
Objective To determine if regional cortical and corpus callosum atrophy and subcortical and periventricular white matter (SPWM) signal changes on head magnetic resonance imaging were specific to CBD.
Design Historical review of autopsy cases.
Setting Subspecialized behavioral neurology and movement disorder clinics within a neurology department of a tertiary referral center.
Patients Seventeen patients with CBS who had an autopsy-confirmed diagnosis of CBD or another neurodegenerative disease.
Main Outcome Measures Regional cerebral cortical atrophy, regional corpus callosum atrophy, and SPWM signal changes.
Results Similar patterns of regional atrophy and SPWM signal changes were found in the patients with autopsy-proven CBD and in the patients with other neurodegenerative diseases.
Conclusion Neither cortical nor corpus callosum atrophy nor SPWM signal changes on head magnetic resonance imaging are specific to CBD.
Author Affiliations: Departments of Neurology (Drs Josephs, Knopman, Petersen, and Boeve), Laboratory Medicine and Pathology (Dr Parisi), Diagnostic Radiology (Dr Jack), and Health Sciences and Research (Drs Edland and Petersen), Mayo Clinic, Rochester, Minn; Department of Neurology (Dr Tang-Wai) and Neuropathology Laboratory (Dr Dickson), Mayo Clinic, Jacksonville, Fla; and Alzheimer’s Disease Research Center, Mayo Foundation, Rochester (Drs Josephs, Edland, Knopman, Dickson, Parisi, Petersen, Jack, and Boeve).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Diffusion-weighted brain imaging study of patients with clinical diagnosis of corticobasal degeneration, progressive supranuclear palsy and Parkinson's disease
Rizzo et al.
Brain 2008;0:awn195v1-awn195.
ABSTRACT
| FULL TEXT
Rates of cerebral atrophy differ in different degenerative pathologies
Whitwell et al.
Brain 2007;130:1148-1158.
ABSTRACT
| FULL TEXT
Corticobasal degeneration and progressive aphasia
McMonagle et al.
Neurology 2006;67:1444-1451.
ABSTRACT
| FULL TEXT
|
