 |
|
Neuroradiological Study of Patients With Amyotrophic Lateral Sclerosis and Parkinsonism–Dementia Complex on the Kii Peninsula of Japan
Yasumasa Kokubo, MD;
Shigeki Kuzuhara, MD
Arch Neurol. 2003;60:1257-1261.
Background The Kii peninsula of Japan, together with Guam and West New Guinea, has one of the highest incidences of amyotrophic lateral sclerosis (ALS) and parkinsonism–dementia complex (PDC) in the world.
Objective To perform neuroimaging studies on patients with ALS and PDC on the Kii peninsula.
Methods Results of computed tomography, magnetic resonance imaging, and single-photon emission computed tomography were studied in 4 patients with ALS and in 10 patients with PDC from the Hohara village on the Kii peninsula of Japan.
Results In patients with PDC, there was mild to severe atrophy of the frontal and temporal lobes on computed tomography and magnetic resonance imaging and a marked decrease in cerebral blood flow on single-photon emission computed tomography. In contrast, in patients with ALS, there was a decrease in cerebral blood flow of the frontal and temporal lobes, although the patients did not show signs of clinical dementia or obvious brain atrophy on computed tomography or magnetic resonance imaging.
Conclusion The finding of an obvious decrease in cerebral blood flow of the frontal and temporal lobes in patients with PDC and ALS with or without cerebral atrophy supports the concept that the 2 conditions are different manifestations of a single frontotemporal tauopathy.
From the Department of Neurology, Mie University School of Medicine, Tsu, Mie-ken, Japan.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
