You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 60 No. 9, September 2003 TABLE OF CONTENTS
  Archives
  •  Online Features
  Original Contribution
 This Article
 •Full text
 •PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on ISI (21)
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Topic Collections
 •Radiologic Imaging
 •Movement Disorders
 •Parkinson Disease/ Parkinsonian Disorders
 •PET/ SPECT Imaging
 •Alert me on articles by topic

Positron Emission Tomography of Striatal Serotonin Transporters in Parkinson Disease

Levente Kerenyi, MD; George A. Ricaurte, MD, PhD; David J. Schretlen, PhD; Una McCann, MD; Jozsef Varga, PhD; William B. Mathews, PhD; Hayden T. Ravert, PhD; Robert F. Dannals, PhD; John Hilton, PhD; Dean F. Wong, MD, PhD; Zsolt Szabo, MD, PhD

Arch Neurol. 2003;60:1223-1229.

Background  Little is known about serotonin neurons in Parkinson disease (PD).

Objective  To study the serotonin system in PD with positron emission tomography, using the serotonin transporter radioligand [11C](+)McN5652.

Design and Patients  We measured the density of the serotonin transporter and the density of [11C]WIN35 428–labeled dopamine transporters in the striatum of 13 adults with PD and 13 age- and sex-matched controls. To assess the effects of possible differences in blood flow or brain atrophy, we also measured regional cerebral blood flow and the size of the regions of interest for the caudate nucleus and putamen.

Results  Patients with PD showed reductions in the specific distribution volumes of [11C](+)McN5652 in the caudate (P<.01) and putamen (P<.01), along with the expected reductions in striatal [11C]WIN35 428 binding (P<.01). There were no reductions in regional cerebral blood flow or the sizes of the regions of interest, mitigating against potential confounding effects of blood flow, brain atrophy, or partial volume effects. Reductions in serotonin transporter binding correlated with ratings of disease staging.

Conclusions  These results suggest that the density of serotonin transporters, like that of dopamine transporters, is reduced in the striatum of patients with PD and that these changes are related to disease stage.


From the Department of Neurology, Medical School Debrecen (Dr Kerenyi); Department of Nuclear Medicine, University of Debrecen (Dr Varga), Debrecen, Hungary; the Department of Radiology, Johns Hopkins Medical Institutions (Drs Ricaurte, Ravert, Dannals, Hilton, Wong, and Szabo), Baltimore Md; the Department of Psychiatry and Behavioral Sciences, School of Medicine (Dr Schretlen and McCann), and the Division of Nuclear Medicine (Dr Mathews), Johns Hopkins University, Baltimore.



THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease
Kish et al.
Brain 2008;131:120-131.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 2003 American Medical Association. All Rights Reserved.